For a cancer patient, whether to vaccinate isn't a simple yes or no — it's "at the right time, with the right vaccine, as decided by your doctor."

During chemotherapy: a suppressed response

Cytotoxic chemotherapy suppresses the immune system, so the body responds less well to vaccines. Vaccination during chemotherapy is therefore generally not recommended — the main exception is the inactivated influenza vaccine, because flu poses a serious threat to cancer patients and this vaccine contains no live virus, making it relatively safe.

Live vaccines: contraindicated

Live attenuated vaccines (for example, the nasal live attenuated flu vaccine) are contraindicated while the immune system is suppressed and should not be given. Inactivated and recombinant vaccines contain no live pathogen and are relatively safe, though the protection they generate during treatment may be weaker.

How long to wait after treatment?

There's no single answer — it depends on the therapy and the vaccine. For instance, after anti-B-cell antibody therapy (a treatment that affects antibody production), it may be six months or more before inactivated vaccines, to allow an adequate response. The exact wait must be judged by your treating doctor.

Why it still matters

If a cancer patient catches flu, pneumococcal disease and the like, the risk of complications is far higher than for the general population. So the real question isn't "should I vaccinate?" but "when, and with which vaccine, is safest and most effective?" Ideally, discuss a vaccination plan with your oncologist before treatment begins; if you're already in treatment, raise it so your doctor can arrange it for you.

This article is general information and is not a substitute for professional medical advice. Discuss any vaccination plan with your oncologist or treating doctor.